A Bump-and-Hole Approach to Dissect Regulation of Protein O-Glycosylation.

Katrine T. Schjoldager*, Henrik Clausen* and Ramon Hurtado-Guerrero*. A Bump-and-Hole Approach to Dissect Regulation of Protein O-Glycosylation. Molecular Cell 78(5):803-805. DOI: 10.1016/j.molcel.2020.05.019 (comment on Molecular Cell, Schumann et al. (2020)), *joint corresponding authorship

In this issue of Molecular Cell, Schumann et al. (2020) present a novel strategy to dissect the regulation of protein O-glycosylation by a large family of isoenzymes in cells. They employ a bump-and-hole engineering approach to capture the specific contribution of individual isoenzymes to O-glycosylation of proteins.

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