Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies and biological evaluation of asymmetrical bispyridinium derivatives.

Rubio Ruiz Belén, Figuerola-Conchas Ainoa, Ramos-Torrecillas Javier, Capitán-Cañadas Fermín, Rios-Marco, Pablo, Carrasco, MªPaz, Gallo, Miguel Angel, Espinosa Antonio, Marco Carmen, Ruiz Concepcion, Entrena Guadix Antonio*, Hurtado-Guerrero Ramon* and Conejo-Garcia Ana*. Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies and biological evaluation of asymmetrical bispyridinium derivatives. Journal of Medicinal Chemistry, 2014. Accepted. * corresponding author