Asymmetric (Transfer) Hydrogenation if Imines

Itziar Peñafiel; Juan Mangas-Sánchez; Carmen Claver, Asymmetric (Transfer) Hydrogenation if Imines in Asymmetric Hydrogenation and Transfer Hydrogenation 2021 Wiley -VCH, pages 281-306

In recent years, enzymatic strategies have emerged as a real alternative to other catalytic approaches for the preparation of chemicals in various industries. Enzymes can operate under mild conditions and often display exquisite selectivity; therefore, they can offer a significant advantage to other synthetic approaches.Due to advances in bioinformatics and molecular biology techniques, the biocatalytic toolbox for the preparation of chiral amines has been greatly expanded in the past decade. To classical approaches such as lipases, transaminases (TAs), or amine oxidases, in recent years, processes involving the asymmetric reduction of prochiral imines have emerged as an alternative and expanded the portfolio of enzymes available for
chiral amine synthesis. In this chapter, different enzymatic approaches involving artificial metalloenzymes and imine reductases (IREDs) for the reduction of imines are discussed.