Construction of Chemoenzymatic Linear Cascades for the Synthesis of Chiral Compounds
C. Ascaso-Alegre and J. Mangas-Sanchez Eur. J. Org. Chem. 2022, e202200
The design of multistep processes to access chiral compounds is a highly dynamic field that benefits from different areas such as chemical catalysis or engineering. This Review discusses recent examples on the construction of linear cascades combining enzyme catalysis with metal and organocatalytic steps, with a focus on the strategies to solve compatibility issues between the different catalytic worlds.
The design of multistep processes to access chiral compounds is a highly dynamic field that benefits from different areas such as chemical catalysis or engineering. This Review discusses recent examples on the construction of linear cascades combining enzyme catalysis with metal and organocatalytic steps, with a focus on the strategies to solve compatibility issues between the different catalytic worlds.