Stereoselective Three-Step One-Pot Cascade Combining Amino- and Biocatalysis to Access Chiral γ-Nitro Alcohols

C. Ascaso-alegre, R. P. Herrera, J. Mangas-Sánchez, Angew. Chem. Int. Ed. 2022, e202209159

Chemoenzymatic cascades offer a simple and efficient way to rapidly build structural complexity. A three-step one-pot process is reported in which a Wittig reaction, chiral-thiourea-mediated asymmetric conjugate addition, and a bioreduction step were combined to access chiral nitro alcohols from commercially available benzaldehyde derivatives in good overall yields and excellent diastereomeric and enantiomeric ratios.

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