Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody

Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody. Javier Macías-León, Iris A. Bermejo, Alicia Asín, Ana García-García, Ismael Compañón, Ester Jiménez-Moreno, Helena Coelho,c Vincenzo Mangini,dInês S. Albuquerque, Filipa Marcelo, Juan L. Asensio, Gonçalo J. L. Bernardes,, Hiren J. Joshi, Roberto Fiammengo, Ola Blixt, Ramón Hurtado-Guerrero,* and Francisco Corzana*. Chemical Communications, 2020. *joint corresponding authorship

The molecular basis of an antibody that recognizes the entire GalNAc unit as a primary epitope has been disclosed. The antibody's contacts with the peptide are limited to mostly two residues, allowing the antibody to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.

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