Uncatalyzed Three-component Synthesis of alfa-Hydrazido Phosphonates

Raquel P. Herrera, David Roca-López, Gloria Navarro-Moros. Uncatalyzed Three-component Synthesis of alfa-Hydrazido Phosphonates. Eur. J. Org. Chem. . 2010, Vol. , p. 1450-2010.

Various α-hydrazido phosphonates have been easily prepared on the basis of nucleophilic addition of dialkylphosphites to reactive preformed N-acylhydrazones and three-component (aldehydes, N-benzoylhydrazide and diphenylphosphite) coupling reaction via non-catalyzed process. An unprecedented and promising enantioselective example of this reaction is also reported