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Ralf Köhler

Aragon Health Sciences Institute (IACS)

Instituto Aragonés de Ciencias de la Salud (IACS)

ARAID Researcher

Education: 

PhD in Biology

Research interests: 

Canales Ionicos en la Investigación Traslacional

Competences: 

Ion channel biophysics

Translational Research

Drug development

Innovative natural cosmetics for skin disease

Cardiovascular and infectious deseases

Facilities and techniques: 

Patch clamp electrophysiology

Generation of genetic animal models for research and drug testing

Genetic screening for rare disease

Drug design

Clinical and cosmetic trials

Links: 

Personal Google Scholar

Relevant publications: 

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes.

Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro-2H-furo[3,2-b]pyrroles, PDE1 Enzyme Inhibitors with an Antiproliferative Effect on Melanoma Cells.

Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis.