Publications

Title Yearsort ascending
Site-Specific O-Glycosylation of Low-Density Lipoprotein Related Receptors Enhance Ligand Interactions. 2018
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. 2018
A perspective on structural and mechanistic aspects of protein O-fucosylation. 2018
Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4 2018
Structural analysis of a GalNAc-T2 mutant reveals an induced-fit catalytic mechanism for GalNAc-Ts. 2018
Structural basis for arginine glycosylation of host substrates by bacterial effector proteins. 2018
The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements 2017
Choline Kinase Inhibition and Docking Studies of a Series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives. 2017
Luteolin can directly inhibit ppGalNAc-Ts and selectively reduce mucin-type O-glycosylation on amyloid precursor protein. 2017
The interdomain flexible linker of the polypeptide GalNAc transferases (GalNAc-Ts) dictates their long-range glycosylation preferences. 2017
NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity. 2017
The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer. 2017
The closed conformation of the LDL receptor is destabilized by the low Ca++ concentration but favored by the high Mg++ concentration in the endosome. 2016
A trapped covalent intermediate of a glycoside hydrolase on the pathway to transglycosylation. Insights from experiments and QM/MM simulations. 2016
Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target. 2016
Rational design of glycomimetic compounds targeting the Saccharomyces cerevisae transglycosylase Gas2. Chemical Biology & Drug Design, 2016
Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-polar Conjugates. 2016
Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine causing Parasite Death. 2016
Mucin Architecture behind the Immune Response: Design, Evaluation and Conformational Analysis of an Antitumor Vaccine Derived from an Unnatural MUC1 Fragment. 2016
Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1). 2016

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