Publications

Title Yearsort ascending
Evidence for substrate-assisted catalysis in N-acetylphosphoglucosamine mutase. 2018
Site-Specific O-Glycosylation of Low-Density Lipoprotein Related Receptors Enhance Ligand Interactions. 2018
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. 2018
A perspective on structural and mechanistic aspects of protein O-fucosylation. 2018
Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4 2018
Structural analysis of a GalNAc-T2 mutant reveals an induced-fit catalytic mechanism for GalNAc-Ts. 2018
The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer. 2017
The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements 2017
Choline Kinase Inhibition and Docking Studies of a Series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives. 2017
Luteolin can directly inhibit ppGalNAc-Ts and selectively reduce mucin-type O-glycosylation on amyloid precursor protein. 2017
The interdomain flexible linker of the polypeptide GalNAc transferases (GalNAc-Ts) dictates their long-range glycosylation preferences. 2017
NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity. 2017
­A proactive role of water molecules in acceptor recognition by Protein-O-fucosyltransferase 2. 2016
Design of alpha-S-neoglycopeptides derived from MUC1 with a flexible and solvent exposed sugar moiety. 2016
The closed conformation of the LDL receptor is destabilized by the low Ca++ concentration but favored by the high Mg++ concentration in the endosome. 2016
A trapped covalent intermediate of a glycoside hydrolase on the pathway to transglycosylation. Insights from experiments and QM/MM simulations. 2016
Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target. 2016
Rational design of glycomimetic compounds targeting the Saccharomyces cerevisae transglycosylase Gas2. Chemical Biology & Drug Design, 2016
Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-polar Conjugates. 2016
Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine causing Parasite Death. 2016

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