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Ana Isabel Gracia Lostao

Universidad de Zaragoza

Instituto de Nanociencia y Materiales de Aragón (INMA) (UZ-CSIC)

Senior Researcher

Education: 

PhD in Biochemistry and Molecular Biology at Universidad de Zaragoza

Research interests: 

Enzymatic mechanisms, molecular recognition pathways, regulatory mechanisms and protein dynamics at the single molecule level

Forces in biology

Integration of biomolecules, molecular magnets, radicals, nanoparticles and polymers on devices to fabricate sensors

Nanomaterials in ferritin

Competences: 

Imaging of biomolecules, complexes, bacteria and cells with sub-nm resolution by fluid AFM

Measurement of intermolecular forces by dynamic force spectroscopy by AFM and optical tweezers

Deposition of biomolecules, molecular magnets, radicals, nanoparticles and polymers at the micro and nanoscale using atomic force lithography and dip-pen nanolithography

Synthesis of magnetic and semiconductor nanoparticles in ferritin

Expression, separation, labeling, functionalization and immobilization of biomolecules and bacteria on surfaces

Facilities and techniques: 

Atomic Force Microscopy imaging; dynamic force microscopy; molecular recognition imaging; mapping of nanomechanical properties

Dip-pen nanolithography

Fast protein liquid chromatography

Keywords: 

Proteins, enzymes, single molecule, forces, AFM, DPN, ferritin, nanomaterials

Links: 

Researchgate

ORCID

QMAD group at INMA

ICTS Laboratorio de Microscopias Avanzadas (UZ)

Relevant publications: 

Nanomechanical study of enzyme:coenzyme complexes: bipartite sites in plastidic ferredoxin-NADP+ reductase for the interaction with NADP+

Enhanced Molecular Spin-Photon Coupling at Superconducting Nanoconstrictions

Detection of a quaternary organization into dimer of trimers of C. ammoniagenes FAD synthetase at the single-molecule level and at the in cell level