Enantioselective alfa- and gamma-Alkylation of alfa,beta-Unsaturated Aldehydes via Dienamine Activation
Julian Stiller, Eugenia Marqués-López, Raquel P. Herrera, Roland Fröhlich, Carsten Strohmann, Mathias Christmann. Enantioselective alfa- and gamma-Alkylation of alfa,beta-Unsaturated Aldehydes via Dienamine Activation. Org. Lett. . 2011, Vol. 13 / 2011, p. 70-2011.
The enantioselective alkylation of α,β-unsaturated aldehydes with stabilized carbocations as electrophiles via the activation as dienamine intermediates is described. This unique application of dienamine catalysis allows for the first enantioselective γ alkylation of linear α,β-unsubstituted enals.
The enantioselective alkylation of α,β-unsaturated aldehydes with stabilized carbocations as electrophiles via the activation as dienamine intermediates is described. This unique application of dienamine catalysis allows for the first enantioselective γ alkylation of linear α,β-unsubstituted enals.